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Developmental Exposure of Male Germ Cells to 5-Azacytidine Results in Abnormal Preimplantation Development in Rats1

1 Nov 1996

Abstract excerpt

Methylation of cytosine residues in mammalian DNA is established during gametogenesis and embryogenesis; it plays an important role in gene regulation and normal embryonic development and has also been implicated in genomic imprinting. In the present study, we evaluated whether paternal administration of 5-azacytidine, a drug that is incorporated into DNA and blocks DNA methylation, could alter male germ cell...

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PMID: 8902229
DOI: 10.1095/biolreprod55.5.1155

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Developmental Exposure of Male Germ Cells to 5-Azacytidine Results in Abnormal Preimplantation Development in Rats1PMID 8902229Read ↗

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