Article
The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.
The EMBO journal - 1 Oct 1996
Yamano H, Gannon J, Hunt T
Abstract excerpt
A cell-free system derived from Xenopus eggs was used to identify the 'destruction box' of the Schizosaccharomyces pombe B-type cyclin, Cdc13, as residues 59-67: RHALDDVSN. Expression of indestructible Cdc13 from a regulated promoter in S.pombe blocked cells in anaphase and inhibited septation, showing that destruction of Cdc13 is necessary for exit from mitosis, but not for sister chromatid separation. In...
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