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A Simple and Efficient Method for the Concentration and Purification of Recombinant Retrovirus for Increased Hepatocyte Transduction <i>In Vivo</i>

10 Sept 1996

Abstract excerpt

Although recombinant retroviruses have been widely used for the transduction of target organs in vivo, the viral titers achieved by current production methods are often too low to achieve therapeutic levels of gene expression. To overcome this limitation, a simple method for the efficient concentration and purification of amphotropic retrovirus particles was developed. After portal vein infusion into partially...

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Identifiers

PMID: 8886844
DOI: 10.1089/hum.1996.7.14-1735

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