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Article

Studies on the Safety of Intrasplenic Hepatocyte Transplantation: Relevance to <i>Ex Vivo</i> Gene Therapy and Liver Repopulation in Acute Hepatic Failure

1 Jun 1993

Abstract excerpt

Hepatocytes transplanted into the host liver engraft promptly, retain normal function, and survive indefinitely. Although intrasplenic transplantation is effective in delivering hepatocytes to the liver, to define potentially limiting complications, we studied its safety in normal, cirrhotic, and partial portal vein-ligated rats. In normal rats, portal pressures increased severalfold after hepatocyte...

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Identifiers

PMID: 8338873
DOI: 10.1089/hum.1993.4.3-249

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Source receipt: pubmed, retrieved 7 Sept 2026.

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