Changes in spleen and thymus cell phenotypes in mice vaccinated with the Coxiella burnetii phase I whole-cell vaccine or the chloroform-methanol residue subunit vaccine.

Abstract excerpt

Lymphoid cell phenotypes within the spleen and thymus were analyzed to determine whether numerical or proportional changes in cell populations could account for the immunosuppression seen after vaccination of mice with inactivated phase I Coxiella burnetii whole-cell vaccine (WCI). Within 21 days of vaccination with WCI, there was a reduction in the percentage of splenic T cells and B cells while the numbers of...

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