Induced protection from a CCHFV-M DNA vaccine requires CD8+ T cells

doi:10.1016/j.virusres.2023.199173

Article

Induced protection from a CCHFV-M DNA vaccine requires CD8+ T cells

24 Jul 2023

Abstract excerpt

Crimean-Congo hemorrhagic fever (CCHF) is a World Health Organization prioritized disease because its broad distribution and severity of disease make it a global health threat. Despite advancements in preclinical vaccine development for CCHF virus (CCHFV), including multiple platforms targeting multiple antigens, a clear definition of the adaptive immune correlates of protection is lacking. Levels of neutralizing...

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