Article
Adjuvants induce distinct immunological phenotypes in a bovine tuberculosis vaccine model.
Clinical and vaccine immunology : CVI - 1 Oct 2009
Vordermeier H Martin, Dean Gillian S, Rosenkrands Ida, Agger Else M, Andersen Peter, Kaveh Daryan A, Hewinson R Glyn, Hogarth Philip J
Abstract excerpt
Tuberculosis (TB) remains one of the most important infectious diseases of humans and animals. Mycobacterium bovis BCG, the only currently available TB vaccine, demonstrates variable levels of efficacy; therefore, a replacement or supplement to BCG is required. Protein subunit vaccines have shown promise but require the use of adjuvants to enhance their immunogenicity. Using the protective mycobacterial antigen...
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