Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease.

The Journal of experimental medicine - 1 Oct 1996

Leusen J H, de Klein A, Hilarius P M, Ahlin A, Palmblad J, Smith C I, Diekmann D, Hall A, Verhoeven A J, Roos D

Abstract excerpt

Chronic granulomatous disease (CGD) is characterized by the failure of phagocytic leukocytes to generate superoxide, needed for the intracellular killing of microorganisms. This is caused by mutations in any one of the four subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. In a rare, autosomal recessive form of CGD, a 67-kD cytosolic component of this enzyme (p67-phox) is missing. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cell Compartmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Mutation

Share to Phosphoproteins

Share to Recombinant Fusion Proteins

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 8879195
DOI: 10.1084/jem.184.4.1243
PMCID: PMC2192830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease.PMID 8879195Read ↗

Molecular characterization of autosomal recessive chronic granulomatous disease caused by a defect of the nicotinamide adenine dinucleotide phosphate (reduced form) oxidase component p67-phox.Semantic proximity Read ↗

Genetic and biochemical background of chronic granulomatous disease.Semantic proximity Read ↗

Genetic, biochemical, and clinical features of chronic granulomatous disease.Semantic proximity Read ↗

Chronic granulomatous disease: the solving of a clinical riddle at the molecular level.Semantic proximity Read ↗

The genetic basis of chronic granulomatous disease.Semantic proximity Read ↗

Clinical, functional and genetic characterization of 16 patients suffering from chronic granulomatous disease variants – identification of 11 novel mutations inCYBBSemantic proximity Read ↗

[Molecular aspects of chronic granulomatous disease. "the NADPH oxidase complex"].Semantic proximity Read ↗

The respiratory burst oxidase and the molecular genetics of chronic granulomatous disease.Semantic proximity Read ↗

Autosomal recessive chronic granulomatous disease caused by novel mutations in NCF-2, the gene encoding the p67-phox component of phagocyte NADPH oxidase.Semantic proximity Read ↗

Chronic granulomatous disease.Semantic proximity Read ↗

Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers.Semantic proximity Read ↗

Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.