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Article

Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1996

Issa J P, Vertino P M, Boehm C D, Newsham I F, Baylin S B

Abstract excerpt

We have previously linked aging, carcinogenesis, and de novo methylation within the promoter of the estrogen receptor (ER) gene in human colon. We now examine the dynamics of this process for the imprinted gene for insulin-like growth factor II (IGF2). In young individuals, the P2-4 promoters of IGF2 are methylated exclusively on the silenced maternal allele. During aging, this promoter methylation becomes more...

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Identifiers

PMID: 8876210
DOI: 10.1073/pnas.93.21.11757
PMCID: PMC38131

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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