Neostriatal dopamine depletion and locomotor abnormalities due to the Albino Swiss rat agu mutation.

doi:10.1016/0304-3940(96)12852-4

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Article

Neostriatal dopamine depletion and locomotor abnormalities due to the Albino Swiss rat agu mutation.

Neuroscience letters - 9 Aug 1996

Campbell J M, Payne A P, Gilmore D P, Byrne J E, Russell D, McGadey J, Clarke D J, Davies R W, Sutcliffe R G

Abstract excerpt

The sub-strain of Albino Swiss rat (AS/AGU) is a spontaneous mutation characterised by an ungainly, staggering gait, hindlimb rigidity, whole body tremor and (when symptoms are fully developed) difficulty in initiating movement; it exhibits a progressive decrease in dopaminergic cells within the...

Topics

Animals
Cell Count
Dopamine
Female
Locomotion
Male
Mutation
Neostriatum
Neurons
Phenotype
Rats
Rats, Mutant Strains
Substantia Nigra
Tyrosine 3-Monooxygenase

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