Article
A frequently occurring mutation in the lipoprotein lipase gene (Asn291Ser) results in altered postprandial chylomicron triglyceride and retinyl palmitate response in normolipidemic carriers.
Journal of lipid research - 1 Aug 1996
Pimstone S N, Clee S M, Gagné S E, Miao L, Zhang H, Stein E A, Hayden M R
Abstract excerpt
An Asn291Ser mutation in exon 6 of the lipoprotein lipase gene (LPL) frequently occurs in Caucasians (2-4%) and results in a partial catalytic defect. Although this mutation may be associated with low HDL cholesterol and elevated triglyceride levels, some carriers are normolipidemic and may have...
Topics
- Adult
- Chylomicrons
- Cohort Studies
- Dietary Fats
- Diterpenes
- Female
- Humans
- Lipoprotein Lipase
- Male
- Middle Aged
- Mutation
- Postprandial Period