Article
Decreased muscle cell proliferation in chicks with a deletion in the GH receptor gene.
Journal of molecular endocrinology - 1 Aug 1996
Goddard C, Johnson R, Gilhooley H J, Gardner J O, Gray A, Wilkie R S, Butterwith S C
Abstract excerpt
The increase in muscle weight in neonatal animals is a consequence of increased protein accretion and DNA content. GH increases protein accretion but direct effects of GH on myogenic cell proliferation have not been demonstrated. Sex-linked dwarfism in the chick is caused by mutation or deletion in the GH receptor gene and has provided a useful model to study the physiological consequences of GH insensitivity....
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