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Article

Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro

4 Jan 2017

Abstract excerpt

Adults who were affected by intrauterine growth restriction (IUGR) suffer from reductions in muscle mass and insulin resistance, suggesting muscle growth may be restricted by molecular events that occur during fetal development. To explore the basis of restricted fetal muscle growth, we used a sheep model of progressive placental insufficiency-induced IUGR to assess myoblast proliferation within intact skeletal...

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PMID: 28053000
DOI: 10.1530/joe-16-0123

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