Article
Effects of hypoxia on drug resistance phenotype and genotype in human glioma cell lines.
Journal of neuro-oncology - 1 Aug 1996
Liang B C
Abstract excerpt
Recurrent gliomas are most often treated by chemotherapy. However, these tumors typically acquire resistance to most drugs administered, and patients will usually die of recurrent tumor. Factors which may play a role include overexpression of putative multidrug resistance genes, such as the multidrug resistance gene 1 (MDR1), multidrug resistance associated protein gene (MRP), 06-alkylguanine, DNA...
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