Article
Candidate gene for the chromosome 1 familial Alzheimer's disease locus.
Science (New York, N.Y.) - 18 Aug 1995
Levy-Lahad E, Wasco W, Poorkaj P, Romano D M, Oshima J, Pettingell W H, Yu C E, Jondro P D, Schmidt S D, Wang K
Abstract excerpt
A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2). The predicted amino acid sequence for STM2 is homologous to that of the recently cloned chromosome 14 AD gene (S182). A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds. This N141l mutation occurs at an amino...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.