Candidate gene for the chromosome 1 familial Alzheimer's disease locus.

doi:10.1126/science.7638622

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Article

Candidate gene for the chromosome 1 familial Alzheimer's disease locus.

Science (New York, N.Y.) - 18 Aug 1995

Levy-Lahad E, Wasco W, Poorkaj P, Romano D M, Oshima J, Pettingell W H, Yu C E, Jondro P D, Schmidt S D, Wang K

Abstract excerpt

A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2). The predicted amino acid sequence for STM2 is homologous to that of the recently cloned chromosome 14 AD gene (S182). A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds. This N141l mutation occurs at an amino...

Topics

Adult
Aged
Alzheimer Disease
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 1
Cloning, Molecular
DNA, Complementary
Female
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Germany

Humans

Lod Score

Male

Membrane Proteins

Middle Aged

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7638622
DOI: 10.1126/science.7638622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7638622-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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