Article
Human mitochondrial DNA diseases.
Advanced drug delivery reviews - 2 Jul 2001
Pulkes T, Hanna M G
Abstract excerpt
The mitochondrial encephalomyopathies are a genetically heterogeneous group of disorders associated with impaired oxidative phosphorylation. Patients may exhibit a wide range of clinical symptoms and experience significant morbidity and mortality. There is currently no curative treatment. At present the majority of genetically defined mitochondrial encephalomyopathies are caused by mutations in mitochondrial DNA....
Topics
- DNA, Mitochondrial
- Genes, rRNA
- Humans
- Mitochondrial Encephalomyopathies
- Phenotype
- Point Mutation
- RNA, Transfer