Article
A regulatory mechanism for the balanced synthesis of membrane phospholipid species in Escherichia coli.
Bioscience, biotechnology, and biochemistry - 1 Jan 1996
Saha S K, Nishijima S, Matsuzaki H, Shibuya I, Matsumoto K
Abstract excerpt
The mechanism that assures the balanced synthesis of zwitterionic (phosphatidylethanolamine) and acidic phospholipids (phosphatidylglycerol and cardiolipin) in Escherichia coli has been examined by genetically manipulating the two enzymes at the biosynthetic branch point, i.e., phosphatidylglycerophosphate synthase, encoded by pgsA, and phosphatidylserine synthase, encoded by pssA. A mutant in which the most part...
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