Article
Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002
Chalasani Geetha, Dai Zhenhua, Konieczny Bogumila T, Baddoura Fady K, Lakkis Fadi G
Abstract excerpt
The allospecifc T cell population responding to a transplanted organ consists of both naive and memory lymphocytes. Although it is established that naive T cells are activated by antigen within the organized structures of secondary lymphoid organs (the spleen, lymph nodes, and mucosal lymphoid tissues), it is not clear whether memory T cell activation and propagation depend on homing to these organs. To answer...
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