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Article

Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines

15 Sept 1996

Abstract excerpt

Human multiple myeloma (MM) represents a highly aneuploid tumor as shown by cytogenetic studies. This may partly explain the heterogeneity with regard to growth factor requirements demonstrated among MM cells. We have previously reported the expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR) mRNA in some MM cell lines. In this study we investigated the role of IGF-I as a growth and/or...

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PMID: 8822946
DOI: 10.1182/blood.v88.6.2250.bloodjournal8862250

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