Article
Linkage disequilibrium between four intragenic polymorphic microsatellites of the NF1 gene and its implications for genetic counselling.
Journal of medical genetics - 1 Jul 1996
Valero M C, Velasco E, Valero A, Moreno F, Hernández-Chico C
Abstract excerpt
Four intragenic polymorphic microsatellite markers, AAAT Alu repeat, IVS27AC28.4, ACI27.2, and IVS38GT53.0, located along a 65 kb DNA region of the NF1 gene, were used to genotype 64 Spanish families with neurofibromatosis type 1 (NF1). Linkage disequilirium between each pair of markers was evalu...
Topics
- Alleles
- Chromosomes
- DNA Primers
- Genes, Neurofibromatosis 1
- Genetic Counseling
- Genetic Markers
- Genotype
- Haplotypes
- Heterozygote
- Homozygote
- Humans
- Linkage Disequilibrium
- Microsatellite Repeats
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Spain