Diagnosis of neurofibromatosis I by using tightly linked, flanking DNA markers.

Article

Diagnosis of neurofibromatosis I by using tightly linked, flanking DNA markers.

American journal of human genetics - 1 May 1990

Ward K, O'Connell P, Carey J C, Leppert M, Jolley S, Plaetke R, Ogden B, White R

Abstract excerpt

We tested 132 individuals from 21 families segregating an allele for neurofibromatosis type 1 (NF-1), by using nine RFLPs tightly linked to the NF-1 locus. Family members had requested DNA testing either to determine whether "at risk" children were carrying the NF-1 allele or to determine whether...

Topics

Alleles
DNA
DNA Probes
Female
Genetic Carrier Screening
Genetic Linkage
Genetic Markers
Humans
Lod Score
Male
Neurofibromatosis 1
Pedigree
Polymorphism, Restriction Fragment Length

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