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Article

Evidence of a long QT founder gene with varying phenotypic expression in South African families.

Journal of medical genetics - 1 Jul 1996

de Jager T, Corbett C H, Badenhorst J C, Brink P A, Corfield V A

Abstract excerpt

We report five South African families of northern European descent (pedigrees 161, 162, 163, 164, and 166) in whom Romano-Ward long QT syndrome (LQT) segregates. The disease mapped to a group of linked markers on chromosome 11p15.5, with maximum combined two point lod scores, all generated at theta = 0, of 15.43 for the D11S922, 10.51 for the D11S1318, and 14.29 for the tyrosine hydroxylase (TH) loci. Recent...

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Identifiers

PMID: 8818942
DOI: 10.1136/jmg.33.7.567
PMCID: PMC1050664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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