Extensive motor neuron survival in the absence of secondary skeletal muscle fiber formation.

Abstract excerpt

Mice with a null mutation in the myogenic basic helixloop-helix regulatory gene myogenin have severe developmental muscle defects resulting in loss of secondary muscle fibers and perinatal death. In this study, we used the myogenin mutant mouse as a model to study the effects of the loss of secondary muscle fibers and the contribution of primary muscle fibers on the survival of motor neurons during programmed...

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