Article
A fluorescent multiplex ARMS method for rapid mutation analysis.
Molecular and cellular probes - 1 Dec 1995
Zschocke J, Graham C A
Abstract excerpt
The amplification refractory mutation system (ARMS) is a powerful technique for the identification of mutations. We present a modification of this technique involving coamplification of normal and mutant alleles with primers that differ in length by three to five bases. Fluorescent labelling allo...
Topics
- Alleles
- Base Sequence
- DNA Mutational Analysis
- DNA Primers
- Fluorescent Dyes
- Genetic Carrier Screening
- Genetic Testing
- Humans
- Molecular Sequence Data
- Northern Ireland
- Phenylalanine
- Phenylketonurias
- Point Mutation
- Polymerase Chain Reaction
- Repetitive Sequences, Nucleic Acid