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Article

Using evolutionary changes to achieve species-specific inhibition of enzyme action--studies with triosephosphate isomerase.

Chemistry & biology - 1 Dec 1995

Gómez-Puyou A, Saavedra-Lira E, Becker I, Zubillaga R A, Rojo-Domínguez A, Pérez-Montfort R

Abstract excerpt

BACKGROUND: Many studies that attempt to design species-specific drugs focus on differences in the three-dimensional structures of homologous enzymes. The structures of homologous enzymes are generally well conserved especially at the active site, but the amino-acid sequences are often very different. We reasoned that if a non-conserved amino acid is fundamental to the function or stability of an enzyme from one...

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PMID: 8807818
DOI: 10.1016/1074-5521(95)90091-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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