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Article

Key residues of loop 3 in the interaction with the interface residue at position 14 in triosephosphate isomerase from Trypanosoma brucei.

Biochemistry - 18 Mar 2008

Cabrera Nallely, Hernández-Alcántara Gloria, Mendoza-Hernández Guillermo, Gómez-Puyou Armando, Perez-Montfort Ruy

Abstract excerpt

Cysteine 14 is an interface residue that is fundamental for the catalysis and stability of homodimeric triosephosphate isomerase from Trypanosoma brucei (TbTIM). Its side chain is surrounded by a deep pocket of 11 residues that are part of loop 3 of the adjacent monomer. Mutation of this residue to serine (producing single mutant C14S) yields a wild-type-like enzyme that is resistant to the action of sulfhydryl...

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PMID: 18298085
DOI: 10.1021/bi702439r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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