Article
Species-dependent post-translational modification and position 2 allelism: effects on streptococcal superantigen SSA structure and V beta specificity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1996
Stevens K R, Van M, Lamphear J G, Orkiszewski R S, Ballard K D, Cook R G, Rich R R
Abstract excerpt
Epidemiologic and molecular population genetic analyses support a role for superantigens (SAg) in the pathogenesis of severe staphylococcal and streptococcal infections. To investigate how variations in SAg structure influence immunomodulatory activity, we examined the biochemical and functional properties of two allelic variants of streptococcal SAg SSA that differ at position 2. Mass spectrometry revealed both...
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