Article
Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor.
The Journal of biological chemistry - 11 Nov 2011
Kouki Annika, Haataja Sauli, Loimaranta Vuokko, Pulliainen Arto T, Nilsson Ulf J, Finne Jukka
Abstract excerpt
Bacterial adhesion is often a prerequisite for infection, and host cell surface carbohydrates play a major role as adhesion receptors. Streptococci are a leading cause of infectious diseases. However, only few carbohydrate-specific streptococcal adhesins are known. Streptococcus suis is an important pig pathogen and a zoonotic agent causing meningitis in pigs and humans. In this study, we have identified an...
Topics
- Adhesins, Bacterial
- Animals
- Cloning, Molecular
- Disaccharides
- Escherichia coli
- Evolution, Molecular
- Gene Expression
- Glycoproteins
- Humans
- Mass Spectrometry
- Mutation
- Protein Binding
- Proteomics