Article
Alteration of acylphosphatase levels in familial Alzheimer's disease fibroblasts with presenilin gene mutations.
Neuroscience letters - 7 Jun 1996
Liguri G, Cecchi C, Latorraca S, Pieri A, Sorbi S, Degl'Innocenti D, Ramponi G
Abstract excerpt
Acylphosphatase (AcPase), an enzyme that modulates the activity of Ca(2+)-ATPase by hydrolysing its phosphorylated moiety, has been found to be significantly higher in cultured skin fibroblasts from donors affected by early onset familial Alzheimer's disease (EOFAD) with PS-1 and PS-2 gene mutations. Of the two known isoenzymes of acylphosphatase, only the erythrocyte one accounts for the total increase in...
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