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Article

Retinoid differentiation therapy in promyelocytic leukemia

1 Jul 1996

Abstract excerpt

Acute promyelocytic leukemia (APL) is a specific type of acute myeloid leukemia characterized by the morphology of the blast cells, a specific t(15;I7) translocation, and risks of definite coagulopathy. Recently this leukemia was further characterized by an exquisite sensitivity to all‐trans retinoic acid's differentiation effect and the production of a fusion gene altering the gene of RARα and a novel gene PML....

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PMID: 8801163
DOI: 10.1096/fasebj.10.9.8801163

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