Interferon action and chromosome 21 trisomy (Down syndrome): 15 years later.

Abstract excerpt

A hypothesis relating interferon action and the chromosome 21 trisomy genotype and phenotype was presented in this journal in 1980. Since that time a number of additional genes involved in interferon action have been mapped to the distal Down Syndrome region of chromosome 21 and a growing literature has documented highly relevant pleiotropic effects of interferon in the brain. Thus, interferon continues to...

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