Increased density of senile plaques (SP), but not neurofibrillary tangles (NFT), in non-demented individuals with the apolipoprotein E4 allele: comparison to confirmed Alzheimer's disease patients.

doi:10.1016/0022-510x(96)00008-1

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Article

Increased density of senile plaques (SP), but not neurofibrillary tangles (NFT), in non-demented individuals with the apolipoprotein E4 allele: comparison to confirmed Alzheimer's disease patients.

Journal of the neurological sciences - 1 Jun 1996

Sparks D L, Scheff S W, Liu H, Landers T, Danner F, Coyne C M, Hunsaker J C

Abstract excerpt

The apolipoprotein E genotype and cortical senile plaque (SP) and cortical and hippocampal neurofibrillary tangle (NFT) densities were determined in non-demented individuals and neuropathologically confirmed AD patients. The non-demented population was further subdivided according to presence or...

Topics

Aged
Aging
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Case-Control Studies
Coronary Disease
Double-Blind Method
Gene Frequency
Genotype
Humans
Middle Aged
Neurofibrillary Tangles

Source

Open in PubMed

Identifiers

PMID: 8791246
DOI: 10.1016/0022-510x(96)00008-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8791246-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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