Article
Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase.
The Journal of biological chemistry - 28 Feb 2003
Pang Siew Siew, Guddat Luke W, Duggleby Ronald G
Abstract excerpt
Acetohydroxyacid synthase (AHAS) (acetolactate synthase, EC ) catalyzes the first step in branched-chain amino acid biosynthesis and is the target for sulfonylurea and imidazolinone herbicides. These compounds are potent and selective inhibitors, but their binding site on AHAS has not been elucid...
Topics
- Acetolactate Synthase
- Binding Sites
- Catalytic Domain
- Crystallography, X-Ray
- Fungal Proteins
- Herbicides
- Imidazoles
- Kinetics
- Models, Chemical
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- Protein Binding
- Protein Conformation
- Protein Structure, Secondary
- Pyrimidines
- Sulfonylurea Compounds