Article
Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.
The Journal of clinical investigation - 1 Sept 1996
Wu J, Wilson J, He J, Xiang L, Schur P H, Mountz J D
Abstract excerpt
The pathogenesis of systemic lupus erythematosus (SLE) is multifactorial and multigenetic. The apoptosis genes, fas and fas ligand (fasL), are candidate contributory genes in human SLE, as mutations of these genes result in autoimmunity in several murine models of this disease. In humans, fas mutations result in a familial autoimmune lymphoproliferative syndrome, but defects in FasL have not yet been identified....
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