Article
Hypersecretion of androgens by polycystic ovaries: the role of genetic factors in the regulation of cytochrome P450c17 alpha.
Bailliere's clinical endocrinology and metabolism - 1 Apr 1996
Franks S, White D, Gilling-Smith C, Carey A, Waterworth D, Williamson R
Abstract excerpt
A single base change has been found in the promoter region of CYP17, the gene encoding P450c17 alpha, which appears to be a significant factor in the expression of hyperandrogenism in PCO but which can be excluded as the primary genetic defect. These findings are consistent with the biochemical data from the studies of patients with PCOS reported above, in which the production of ovarian 17 hydroxyprogesterone...
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