Article
Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17.
Human molecular genetics - 1 Oct 1994
Carey A H, Waterworth D, Patel K, White D, Little J, Novelli P, Franks S, Williamson R
Abstract excerpt
Fourteen Caucasian families with 81 affected individuals have been assessed in which polycystic ovaries/male pattern baldness (PCO/MPB) segregates as an autosomal dominant phenotype (1). The gene CYP17, coding for P450c17 alpha (17 alpha-hydroxylase; 17/20 lyase) on chromosome 10q24.3 is the rate...
Topics
- Alleles
- Alopecia
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- DNA Primers
- Female
- Humans
- Lod Score
- Male
- Molecular Sequence Data
- Pedigree
- Point Mutation
- Polycystic Ovary Syndrome
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Promoter Regions, Genetic
- Random Allocation