Article
Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone.
The American journal of physiology - 1 Jan 1996
Martinez D A, Orth M W, Carr K E, Vanderby R, Vailas A C
Abstract excerpt
The growth hormone (GH)-deficient dwarf rat was used to investigate recombinant human (rh) GH-induced bone formation and to determine whether rhGH facilitates simultaneous increases in bone formation and bone maturation during rapid growth. Twenty dwarf rats, 37 days of age, were randomly assigned to dwarf plus rhGH (GH; n = 10) and dwarf plus vehicle (n = 10) groups. The GH group received 1.25 mg rhGH/kg body wt...
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