Article
[The impact of the 4-year human recombinant growth hormone treatment on growth, body composition and bone mineral density in patients with isolated growth hormone deficiency and multihormonal pituitary insufficiency].
Przeglad lekarski - 1 Jan 2010
Januś Dominika, Wójcik Małgorzata, Zygmunt-Górska Agata, Dolezal-Ołtarzewska Katarzyna, Starzyk Jerzy
Abstract excerpt
BACKGROUND: In addition to stimulating bone growth in length, human recombinant growth hormone (rhGH) significantly affects in a direct and IGF-I-mediated manner body composition (body fat/lean body mass ratio) and skeletal maturation in vitro and in vivo. The direct role of rhGH on bone mineralization and its effect on bone mineral density is controversial. AIM: To compare growth and body composition, bone...
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