Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.

doi:10.1128/JVI.64.7.3207-3211.1990

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Article

Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.

Journal of virology - 1 Jul 1990

Gorelick R J, Nigida S M, Bess J W, Arthur L O, Henderson L E, Rein A

Abstract excerpt

All retroviruses contain, in the nucleocapsid domain of the Gag protein, one or two copies of the sequence Cys-X2-Cys-X4-His-X4-Cys. We have generated a series of mutants in the two copies of this motif present in human immunodeficiency virus type 1. These mutants encoded virus particles that wer...

Topics

Amino Acid Sequence
Capsid
Cysteine
DNA Mutational Analysis
Gene Products, gag
HIV-1
HeLa Cells
Molecular Sequence Data
Morphogenesis
Mutation
RNA, Viral
Viral Core Proteins
Virus Replication

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