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Article

Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.

Journal of virology - 1 Jul 1990

Gorelick R J, Nigida S M, Bess J W, Arthur L O, Henderson L E, Rein A

Abstract excerpt

All retroviruses contain, in the nucleocapsid domain of the Gag protein, one or two copies of the sequence Cys-X2-Cys-X4-His-X4-Cys. We have generated a series of mutants in the two copies of this motif present in human immunodeficiency virus type 1. These mutants encoded virus particles that were apparently composed of the normal complement of viral proteins but contained only 2 to 20% of the normal level of...

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Identifiers

PMID: 2191147
DOI: 10.1128/JVI.64.7.3207-3211.1990
PMCID: PMC249531

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