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Article

Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice.

The Journal of investigative dermatology - 1 Aug 1996

Starcher B, O'Neal P, Granstein R D, Beissert S

Abstract excerpt

In this study we investigated whether a reduction in neutrophil elastase activity in mice would alter the development of ultraviolet B or chemically induced skin tumors. A mutant strain of neutrophil elastase-deficient mice was developed by crossing beige mice with SKH 1 hairless mice. Ultraviolet irradiation three times per week for 20 wk developed an average of 10 tumors per normal mouse, whereas...

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Identifiers

PMID: 8757756
DOI: 10.1111/1523-1747.ep12329559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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