Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice.

doi:10.1111/1523-1747.ep12329559

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Article

Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice.

The Journal of investigative dermatology - 1 Aug 1996

Starcher B, O'Neal P, Granstein R D, Beissert S

Abstract excerpt

In this study we investigated whether a reduction in neutrophil elastase activity in mice would alter the development of ultraviolet B or chemically induced skin tumors. A mutant strain of neutrophil elastase-deficient mice was developed by crossing beige mice with SKH 1 hairless mice. Ultraviole...

Topics

Animals
Benzopyrenes
Dermatitis, Contact
Genetic Predisposition to Disease
Kinetics
Leukocyte Elastase
Mice
Mice, Hairless
Neoplasms, Radiation-Induced
Oligopeptides
Skin Neoplasms
Ultraviolet Rays

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