Article
Nondeletional alpha-thalassemia: first description of alpha Hph alpha and alpha Nco alpha mutations in a Spanish population.
American journal of hematology - 1 Jul 1996
Ayala S, Colomer D, Aymerich M, Pujades A, Vives-Corrons J L
Abstract excerpt
Several different deletions underlie the molecular basis of alpha-thalassemia. The most common alpha-thalassemia determinant in Spain is the rightward deletion (-alpha 3.7). To our knowledge, however, no cases of alpha-thalassemia due to nondeletional mutations have so far been described in this...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Base Sequence
- Child, Preschool
- DNA Restriction Enzymes
- Female
- Gene Deletion
- Heterozygote
- Humans
- Male
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Spain
- alpha-Thalassemia