Article
alpha-globin genes: thalassemic and structural alterations in a Brazilian population.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Sept 2000
Wenning M R, Kimura E M, Costa F F, Saad S T, Gervásio S, de Jorge S B, Borges E, Silva N M, Sonati M F
Abstract excerpt
Seven unrelated patients with hemoglobin (Hb) H disease and 27 individuals with alpha-chain structural alterations were studied to identify the alpha-globin gene mutations present in the population of Southeast Brazil. The -alpha3.7, --MED and -(alpha)20.5 deletions were investigated by PCR, whereas non-deletional alpha-thalassemia (alphaHphalpha, alphaNcoIalpha, alphaalphaNcoI, alphaIcalpha and alphaTSaudialpha)...
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