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Article

Genetic separation of tumor growth and hemorrhagic phenotypes in an estrogen-induced tumor.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 1996

Wendell D L, Herman A, Gorski J

Abstract excerpt

Chronic administration of estrogen to the Fischer 344 (F344) rat induces growth of large, hemorrhagic pituitary tumors. Ten weeks of diethylstilbestrol (DES) treatment caused female F344 rat pituitaries to grow to an average of 109.2 +/- 6.3 mg (mean +/- SE) versus 11.3 +/- 1.4 mg for untreated rats, and to become highly hemorrhagic. The same DES treatment produced no significant growth (8.9 +/- 0.5 mg for...

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Source

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Identifiers

PMID: 8755612
DOI: 10.1073/pnas.93.15.8112
PMCID: PMC38884

Genes

DES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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