Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single chain Ig/γ gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity

1 Jul 1996

Abstract excerpt

To enable construction of CTL with known predefined Ab specificity for adoptive immunotherapy, we constructed a chimeric scFv/gamma gene composed of the variable regions of a mAb joined to the Fc(epsilon)RI signaling receptor gamma-chain of mast cells. Introduction of this chimeric receptor into CTL rendered these lymphocytes specific for renal cell carcinoma. This approach combines the specificity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immunotherapy and Immune Responses
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8752936
DOI: 10.4049/jimmunol.157.2.836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single chain Ig/γ gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacityPMID 8752936Read ↗

A novel single TCR gamma chain fused with antibody-based binding domain facilitates T cell cytotoxicity for potent anti-tumor response without forming TCR-CD3 complexSemantic proximity Read ↗

Immunotherapy of Cancer Using Systemically Delivered Gene-Modified Human T LymphocytesSemantic proximity Read ↗

Evolution of cell therapy for renal cell carcinomaSemantic proximity Read ↗

Adoptive Cell TherapySemantic proximity Read ↗

Adoptive immunotherapy for cancer: the next generation of gene‐engineered immune cellsSemantic proximity Read ↗

T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignanciesSemantic proximity Read ↗

Expansion and characterization of T cells transduced with a chimeric receptor against ovarian cancer.Semantic proximity Read ↗

Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applicationsSemantic proximity Read ↗

FCγ Chimeric Receptor-Engineered T Cells: Methodology, Advantages, Limitations, and Clinical RelevanceSemantic proximity Read ↗

A human cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM overexpressing tumor cells.Semantic proximity Read ↗

Monoclonal T-Cell Receptors: New Reagents for Cancer TherapySemantic proximity Read ↗

Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of toleranceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.