Article
HLA-DR5 and DQB1*03 class II alleles are associated with cutaneous T-cell lymphoma.
The Journal of investigative dermatology - 1 Sept 1996
Jackow C M, McHam J B, Friss A, Alvear J, Reveille J R, Duvic M
Abstract excerpt
Cutaneous T-cell lymphoma (CTCL) may present with eczematous lesions, mycosis fungoides (MF), or as exfoliative erythroderma with circulating atypical cells, Sezary syndrome (SS). The "malignant" T cells are epidermotropic and clonal, but whether they respond to antigen stimulation is unknown. Because CD4+ lymphocytes recognize antigen presented by histocompatibility locus antigen (HLA) class II molecules, and...
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