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Article

Low FAS/CD95 expression by CTCL correlates with reduced sensitivity to apoptosis that can be restored by FAS upregulation.

The Journal of investigative dermatology - 1 May 2009

Wu Jianqiang, Nihal Minakshi, Siddiqui Jawed, Vonderheid Eric C, Wood Gary S

Abstract excerpt

FAS expression was generally low in 30 of 31 cutaneous T-cell lymphoma (CTCL) cases (mycosis fungoides/Sezary syndrome, SS) as well as in 5 of 6 large plaque parapsoriasis cases (a CTCL precursor). To investigate this phenomenon, we explored FAS transcript levels, cell-surface FAS protein express...

Read the complete abstract on PubMed

Topics

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Share to Apoptosis
Share to Fas Ligand Protein
Share to fas Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Lymphoma, T-Cell, Cutaneous

Share to Mycosis Fungoides

Share to Skin Neoplasms

Share to Up-Regulation

Source

Identifiers

PMID: 18923451
DOI: 10.1038/jid.2008.309

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18923451-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Low FAS/CD95 expression by CTCL correlates with reduced sensitivity to apoptosis that can be restored by FAS upregulation.PMID 18923451Read ↗

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