Article
Molecular analysis and predictive testing in retinoblastoma.
Ophthalmic genetics - 1 Dec 1995
Lohmann D R, Brandt B, Oehlschläger U, Göttmann E, Höpping W, Passarge E, Horsthemke B
Abstract excerpt
Predictive testing using molecular analysis is an integral part of contemporary retinoblastoma management. We have made extensive use of segregation analysis for risk assessment in both familial and sporadic disease. Investigation of loss of heterozygosity in tumor samples proved to be invaluable for the identification of linkage phase. In many families, however, accurate carrier risk assessment depends on direct...
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