Article
Association analyses of NsiI RFLP of human insulin receptor gene in hypertensives.
Clinical genetics - 1 Feb 1996
Schrader A P, Zee R Y, Morris B J
Abstract excerpt
Plasma angiotensinogen is elevated in essential hypertensives and shows a strong correlation with blood pressure. Patients with hypertension often display insulin resistance and we have found previously an association of a RsaI RFLP in intron 9 of the insulin receptor gene (INSR) with hypertension. Since insulin resistance is accompanied by hyperinsulinaemia and insulin can stimulate angiotensinogen production,...
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