Effects of physical activity and age on mitochondrial function.

doi:10.1093/qjmed/89.4.251

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Article

Effects of physical activity and age on mitochondrial function.

QJM : monthly journal of the Association of Physicians - 1 Apr 1996

Brierley E J, Johnson M A, James O F, Turnbull D M

Abstract excerpt

It has been proposed that ageing results from the accumulation of mitochondrial DNA mutations with age which interfere with respiratory chain ATP production. Insufficient ATP production impairs cell function, and tissue dysfunction ensues, leading to morbidity, decline and eventually death. Supporting this theory, mitochondrial DNA mutations accumulate with age and respiratory chain function declines dramatically...

Topics

Adult
Aged
Aged, 80 and over
Aging
DNA, Mitochondrial
Exercise
Female
Humans
Male
Middle Aged
Mitochondria, Muscle
Muscles
Mutation
Oxidative Stress

Source

Open in PubMed

Identifiers

PMID: 8733511
DOI: 10.1093/qjmed/89.4.251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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