Article
Regulation by neurotransmitter receptors of serotonergic or catecholaminergic neuronal cell differentiation.
The Journal of biological chemistry - 31 Mar 2000
Mouillet-Richard S, Mutel V, Loric S, Tournois C, Launay J M, Kellermann O
Abstract excerpt
The murine F9-derived 1C11 clone exhibits a stable epithelial morphology, expresses nestin, an early neuroectodermal marker, and expresses genes involved in neuroectodermal cell fate. Upon appropriate induction, 100% of 1C11 precursor cells develop neurite extensions and acquire neuronal markers (N-CAM, synaptophysin, gammagamma-enolase, and neurofilament) as well as the general functions of either serotonergic...
Topics
- Animals
- Cell Differentiation
- Cell Line
- Down-Regulation
- Neurons
- Norepinephrine
- Phenotype
- Receptors, Adrenergic
- Receptors, Adrenergic, alpha-1
- Receptors, Serotonin
- Serotonin
